Advanced Health & Life Extension
Custom Search
Home |   Research Page |   Contact |  
Alphabetical List of Articles
4 Thieves Vinegar
Beta Glucan
Bird Flu
Bird Flu Links
Body Mass Index
Coconut Oil
Cold Sores
Colloidal Silver
Conjugated Linoleic Acid
Coral Calcium
Curcumin & Turmeric
Fitness Nutrition
Flu & Colds
Good Fats
Green Tea
Lysine & Herpes
Metabolic Syndrome
N-Acetyl Cysteine
Nuclear Fallout
Olive Leaf Ext
Omega-3 EFAs
Oral Chelation
Proteolytic Enzymes
R Lipoic Acid
Red Wine
Sleep & Insomnia
St. Johns Wort
Thymic Protein A
Vision Quest
Vital Energy
Vitamin A
Vitamin B12
Vitamin C
Vitamin D
Weight Loss

Life Extension Foundation® Home
Successful Strategies to fight Obesity and Weight Gain
Read the full Article on Successful Strategies to fight Obesity and Weight Gain

Forskolin - Coleus Forskohlii

      Forskolin (7 beta-acetoxy-8, 13-epoxy-1 alpha,6 beta,9 alpha-trihydroxy-labd-14-ene-11-one) is the main active ingredient in the Ayurvedic herb Coleus forskohlii. Coleus is a member of the mint family and grows in subtropical areas in India, Burma, and Thialand. Forskolin has been extensively researched in the medical field for use in the treatment of allergies, respiratory problems, cardiovascular diseases, glaucoma, psoriasis, hypothyroidism and weight loss. Forskolin increases Cyclic AMP and appears to have additional actions that are due to its ability to alter a number of membrane transport proteins.

Effects of Coleus on Cyclic AMP

      Increased cellular cyclic AMP results in inhibition of platelet activation, decreased likelihood of blood clots, reduced release of histamine, decreased allergy symptoms, increased force of contraction of the heart, relaxation of the arteries and other smooth muscles, increased thyroid function, increased fat metabolism, increased energy and possibly weight loss. Cyclic AMP and the chemicals it activates comprise a second messenger system that is responsible for carrying out the complex and powerful effects of hormones in the body.

      In addition, asthma, eczema, psoriasis, angina, obesity and hypertension are believed to be associated with decreased Cyclic AMP.

Coleus and Glaucoma

      Glaucoma is a condition in which the pressure in the eye is too high, due to an imbalance between the formation of aqueous humor in the eye and its absorption in or drainage out of the eye. Eventually, as the pressure builds up, the blood vessels nourishing the optic nerve are constricted, resulting in irreversible damage to the nerve and impaired vision culminating in blindness, if left untreated.

      While there are no clinically proven alternative therapies for glaucoma, there are several treatments that may be beneficial and coleus is one of them. Clinical studies have shown that topical application of one percent forskolin eye drops resulted in significant decreases in intraocular pressure for up to five hours. Limited clinical experience suggests that oral forskolin appears to offer significant potential for sufferers of glaucoma. An Indian pharmaceutical company is currently engaged in clinical trials of a forskolin eye drop product.

Coleus and Depression

      Depression is believed to be associated with an imbalance of neurotransmitters in the brain, serotonin and dopamine primarily. Where there is a shortage of serotonin, the supplements 5-HTP or tryptophan or the SSRI drugs like prozac or Zoloft may be beneficial. If the catecholamine neurotransmitters (epinephrine, norephinephrine) are deficient the amino acids L-Phenylalanine or L-Tyrosine, or monoamine oxidase inhibitors like GeroVital (GH3) or Deprenyl are may be helpful. Recent research has also been evaluating drugs that increase Cyclic AMP as a means of elevating the catecholamines. Since forskolin elevates Cyclic AMP, it may improve neurotransmitter function and thereby relieve depression. Clinical trials using coleus to treat depression have not been done.

Coleus with Asthma and Allergies

      Coleus is an effective smooth muscle relaxer, resulting in bronchodilation, decreased airway resistance, increased vital capacity and increased forced expiratory volume. This action is the result of the increase in Cyclic AMP caused by coleus. Many asthma medications increase Cyclic AMP by inhibiting the enzymes that cause its breakdown. Thus, coleus and the traditional asthma drugs are likely to act synergistically. Therefore, one should consult their physician before combining them.

Coleus and Weight Loss

      In vitro (studies done in the lab) studies show that coleus stimulates fat metabolism. Researchers have found that many obese people have lower than normal Cyclic AMP production. Because of these considerations, coleus may, theoretically, be a weight loss agent, especially for those with reduced Cyclic AMP production. In a recent study, six overweight women took 25 mg of coleus (250 mg capsules of 10% standardized forskolin extract) twice daily for eight weeks. At the end of the eight-week trial, the participants lost a mean of ten pounds, and reduced their percentage of body fat by nearly 8%. Blood pressure levels also trended lower during the trial.

Coleus and Hypothyroidism

      Forskolin has demonstrated the ability to increase thyroid hormone production and stimulate thyroid hormone release.

Coleus and Cancer Metastases

      Reserch has shown coleus to be a potent inhibitor of tumor colonization in mice. It is theoretically possible that coleus could be used in humans to prevent or inhibit tumor metastases.

Coleus and Immune Enhancement

      Forskolin appears to exhibit potent immune system enhancement by activating macrophages and lymphocytes.

Coleus and Psoriasis

      In psoriasis, cells divide about 1,000 times faster than normal. Coleus helps to alleviate psoriasis by normalizing the cAMP /cGMP ratio.

Cardiovascular Effects of Coleus

      Coleus forskohlii has traditionally been used to treat hypertension, congestive heart failure, and angina. Coleus's basic cardiovascular action is to lower blood pressure, while simultaneously increasing the contractility of the heart. This is believed to be due to forskolin's Cyclic AMP-elevating ability, which results in relaxation of the arteries, and increased force of contraction of the heart muscle. A preliminary trial found that coleus reduced blood pressure and improved heart function in people with cardiomyopathy. Coleus also increases cerebral blood flow, indicating that it may be beneficial in cerebral vascular insufficiency, and in enhancing post-stroke recovery. The platelet aggregation-inhibiting effects of coleus also adds to its value in cardiovascular disorders.

Drug Interactions with Coleus

      There is some evidence that forskolin may enhance the effects of beta-agonists such as albuterol. Forskolin may also act synergistically with epinephrine, ephedrine and pseudoephedrine. It is possible that the use of forskolin may decrease the needed dosages of beta-agonists. Anyone taking these drugs should consult their physician if they want to also use forskolin.

      Because forskolin inhibits platelet aggregation and clotting, it may enhance the effects of anti-clotting medications such as warfarin, clopidogre, aspirin, enoxaparin, and dalteparin. Anyone taking any anti-clotting medications or supplements should consult their physician before adding forskolin to their regimen.

Coleus Dosage

      There is very limited information from clinical studies on the safe and effective dosages of forskolin. Based on the human studies for weight loss, 50 to 100 mg of forskolin taken in divided doses during the day appears to be an appropriate dose for the conditions discussed above.

Search Life Extension Health Protocols

Life Extension Disease Prevention and Treatment protocols

Search Life
Extension Magazine

Life Extension Magazine


Disclaimer: The information in this article and on this website is not intended to diagnose, treat, cure or prevent any disease. None of the products mentioned in this article or on this website are intended to diagnose, treat, cure or prevent any disease. The information in this article is not intended to provide personal medical advice, which should be obtained from a medical professional. This information is made available with the understanding that the author and publisher are not providing medical, psychological, or nutritional counseling services on this site. The information on this Web site does not cover all possible uses, actions, precautions, side effects, and interactions. Liability for individual actions or omissions based upon the contents of this site is expressly disclaimed. This information has not been evaluated or approved by the U.S. FDA.

Home |   Research LinksContact |   Privacy Policy |  

copyright 2017 Clear Springs Press, LLC. All rights reserved.
Life Extension
Life Extension Foundation® Home
Vitamin, Life Extension, Life Extension Foundation, buy vitamins, buy dietary supplements, quality vitamins, quality supplements, nutrition products, leading nutrition, quality vitamin company,

Supplements Guide
Supplements A to Z
Latest Supplements
12 Best Supplements

Supplements by

All Vitamins
All Minerals
Fish Oil Omega 3
Herbs Botanicals
Amino Acids
Skin Care
Sports Performance
Immune Support
Blood Testing
Inflammation Management
Joint Support
Weight Management
Heart Health
Brain Health
Bone Health
Digestion Support
Cholesterol Management
Energy Management
Mood and Stress
Liver and Detox
Blood Pressure
Glucose Management
Thyroid Health
Kidney and Bladder
Eye Health
Adrenal Health
Childrens Health
Mens Health
Womens Health

There are Seven Pillars of Successful Weight Loss - Read More