Hypoadrenia & Stress

      Our adrenal glands are actually two glands in close proximity. The adrenal medula is actually an extension of the nerve cells of the sympathetic nervous system. When stimulated, they secrete adrenaline, a neurotransmitter which causes specific physiological responses that enable the body to call forth the extreme strength, speed and reaction time that is necessary for survival when confronted by a saber-toothed tiger. The second part, the adrenal cortex, is stimulated by pituitary hormones to release adrenal cortical hormones, such as cortisol. The adrenal cortical hormones suppress inflammatory processes, healing processes and the immune system. They also convert glycogen stores into glucose and elevate blood sugar levels. Collectively, these responses put the body on RED ALERT and divert all available energy and raw materials to immediate survival tasks.

      When our ancestors were stalking dangerous food or trying desperately to avoid becoming food they would experience a classical stress response through a series of events that had a defined beginning and end. Today, our bodies engage in that same stress response, except that there is no clear end to it. Repeated and prolonged stress exhausts the adrenal glands and other glands and organ systems. Hypoadrenia is one of the results. Hypothyroidism, reactive hypoglycemia and depressed immunity are often associated with this condition as well. For more information on the Stress Response, read the article on Stress.

Symptoms of Hypoadrenia

      Here are some general symptoms of adrenal insufficiency, adrenal exhaustin or hypoadrenia.

      Excessive Fatigue
      Light headedness (or dizzyness, etc.) upon standing
      Cravings for sweets
      Alcohol Intolerance
      Hypoglycemia (low blood sugar)
      Poor resistance to infections (in general)
      Chronic Infections
      Chronic Allergies
      Skin, Dry &/or "thin"
      Low Blood Pessure
      Easily irritated
      General Nervouseness
      Weakness
      Anxiety/Depression/Fearfullness
      Food "sensitivities", or inhalant allergies
      Become emotional after eating sweets or starches
      Hard to gain weight or to build muscle mass
      Poor Memory
      Excessive hunger
      Low tendency to perspire
      Dark circles under eyes
      Indigestion, "Pit" of stomach, distress/pain
      Insomnia
      Tenderness in adrenal area
      Low Sex Drive

      If you answered yes to 5 or more of the above, you might be experiencing symptoms of hypoadrenia. There may be other causes or explanations as well. To investigate further, do the Postural Hypotension Test for Hypoadrenia.

The Postural Hypotension Test for Hypoadrenia

      There are a number of laboratory tests that can be performed to evaluate cortisol, dhea and other hormone levels. One clinical test that anyone can perform for free at home is the "Postural Hypotension" test or "Raglans" test. For this you need a blood pressure cuff and the knowledge to use it. Blood pressure cuffs can be obtained at nearly any drugstore and the staff will usually assist you with its use if you need help.

      (1) Start in a recumbent (on your back) position. You need to lie down long enough to be in a relaxed state. While lying on your back in a relaxed state, take and record your blood pressure.

      (2) Inflate the blood pressure cuff and prepare to take a reading. Immediately stand up and take the reading in the standing position and record it.

      (3) Normally, with the help of your sympathetic nervous system of which the adrenal glands are a part, your blood pressure will rise between 4 and 10 points (mm/Hg) when going from the lying to the standing position. If your blood pressure drops, it may be an indication of hypoadrenia. If your blood pressure drops noticably, you may also feel a little faint upon standing.

Stress Hormones

      There are two hormones of particular interest here, Cortisol and DHEA. Cortisol is a powerful steroid released to "activate" your body in times of stress. You need cortisol to "pump you up"' to meet all the daily challenges of life. Without it you'd have no motivation to even get out of bed in the morning! But if your body produces too much cortisol over a long period of time, it can disrupt your blood sugar metabolism, trigger emotional problems, and make you feel constantly tired and weak. Eventually, chronic elevated cortisol levels can lead to weight gain, muscle and joint pain, insomnia, impaired immune function and premature aging.

      DHEA is the most abundant hormone in your bloodstream. DHEA seems to balance the effects of cortisol by improving the body's ability to cope with stress. It also provides the source material for the production of many other hormones including sex hormones. Clinical studies suggest that DHEA can boost energy levels, strengthen immune function, improve memory, and reduce body fat. Some researchers believe that DHEA acts as a "mood elevator," preventing depression and senile dementia by protecting important neurons in the brain. DHEA levels should be closely monitored when supplementing, however, to prevent potentially harmful imbalances. Also, DHEA supplementation is generally inappropriate for individuals under age 40.

The Consequences of Chronic High Cortisol

      To repeat, chronically elevated cortisol levels contribute to the accumulation of abdominal fat and make it very difficult to get rid of it. The immune system is suppressed and the individual becomes more susceptible to infections, both minor and major. Clerly, we would like for our cortisol levels to return to normal.

How to Correct your Cortisol Level and Hypoadrenia

      Stress reduction is an essential part of all efforts to normalize cortisol. Stress is the stimuli that caused the cortisol levels to get out of hand to begin with. Each individual should explore and find the stress reduction techniques that work best for themselves. Meditation, physical activities, attitude changes etc. are good paths to explore. Without stress reduction, all therapeutic and support measures will eventually fail.

      Rest. This may sound obvious but it must be managed and scheduled as a deliberate strategy, choice and course of action. Otherwise it gets forgotten in the busyness of life.

      A low glycemic diet is important. Sugar handling stress increases cortisol levels. Elevated cortisol, in turn, aggravates the sugar handling situation contributing to the development of high insulin levels and ultimately diabetes.

      Nutritional supplementation is very valuable in restoring normal cortisol levels. It is important, however, to recognize if your cortisol levels are high or low. Low cortisol levels are the consequence of adrenal exhaustion or the exhaustion phase of the stress response. High cortisol levels are the result of the response to chronic stress and represent the adaptation phase of the stress response.

Nutritional Supplements to Support Low or High Cortisol Levels

      For basic adrenal support, include:

• A good Complete Multiple Vitamin Mineral Supplement.
  
• Vitamin C, one capsule (500 to 1000 mg.) three times per day.
  
• B5, (500 mg.)one capsule per day
  
• B6, (50 mg.) one capsule per day

      One of the best known and most effective ways to lower excess cortisol levels is with the nutrient Phosphatidylserine (PS). Phosphatidylserine is believed to facilitate the repair of the cortisol receptors in the hypothalamus. It is believed that the cortisol receptors get damaged by high cortisol levels reducing the ability of the hypothalamus to sense and correct high cortisone levels. Because Phosphatidylserine helps repair the feedback control apparatus, it is useful in correcting both high and low cortisol levels. Phosphatidylserine is also useful for preventing short-term memory loss, age-related dementia and Alzheimer's disease. Typical dosages are one to three 100 mg. capsules per day.

      Adaptogens are an entire category of herbs that assists the body in coping with stress by restoring hypothalamic cortisol receptor sensitivity. Ginseng Adreno-Build 4050 is one such blend of adaptogenic herbs. It is a combination of eleuthero, American ginseng and rhodiola, all researched for their effects on increasing stamina, mental alertness and work performance. Botanical catalysts support the action of the formula by enhancing endurance and nourishing the adrenal glands, featuring ashwagandha, Chinese licorice and rehmannia. Typical dosages one tablet (4050 mg. herbal blend) per day.

      Relora® is a patent pending plant extract of Phellodendron amurense and Magnolia officinalis that may help to relieve stress and minimize stress-induced eating. Weight gain can be associated with emotional over-eating for people with stressful lifestyles. Preliminary research suggests that Relora® may help regulate cortisol levels in the body that are associated with stress-related weight gain. The bark of Magnolia officinalis has been used in traditional Chinese Herbalism for centuries for stress reduction and muscle tension.

      DHEA is a hormone which acts as a precursor for many other hormones. DHEA levels decline drastically with age. Many anti-aging physicians and programs advocate DHEA supplementation for individuals over 40 years of age. There is some medical controversy regarding this practice. If you are considering taking DHEA supplements, it would be a good idea to use the tests to both determine the need for it and get the dosage adjusted properly. DHEA can also be used empirically to alleviate the symptoms of excess cortisol or hyperadaptosis. DHEA can improve glucose tolerance, convert excess body fat to lean muscle mass, alleviate depression, increase energy and decrease pain in chronic fatigue and fibromyalgia patients, decrease joint pain and fatigue in inflammatory and autoimmune diseases, improve mental clarity and enhance overall immune function. Typical doses for DHEA are 10 to 25 mg for women, 25 to 100 mg for men, taken in the morning to mimick the bodys natural rhythm. Note: Dosage should be adjusted based on test results. It is important for men to take a prostate PSA test before supplementation. DHEA supplementation could potentially complicate prostate cancer, so professional medical advice is necessary if the PSA level should be elevated.

      Adrenal exhaustion is more difficult to resolve. Adrenal exhaustion involves a depletion of energy reserves and a loss of resilience. Symptomatic signs of adrenal exhaustion can be as diverse as fatigue, nervousness, anxiety, severe PMS, depression, brain fog, carbohydrate cravings, allergies, muscular pain and tenderness, joint pain and irritable bowel syndrome. The goal of nutritional therapy in this situation is to restore the natural, diurnal release of normal levels of cortisol. The theory is if you provide the body with a small amount of a cortisol-like substance, the adrenal glands can take a rest and have an opportunity to regenerate. Then normal cortisol production will be restored.

Articles Related to Adrenal Status

      Read this article on Cortisol in Life Extension Magazine.

      Read Life Extension Disease Prevention and Treatment Protocols on Adrenal Diseases.

Products Related to Adrenal Support

Relora 250 mg, 45 tablets Relora® is a patent pending plant extract of Phellodendron amurense and Magnolia officinalis that may help to relieve stress and minimize stress-induced eating. Weight gain can be associated with emotional over-eating for people with stressful lifestyles. Preliminary research suggests that Relora® may help regulate cortisol levels in the body that are associated with stress-related weight gain. The bark of Magnolia officinalis has been used in traditional Chinese Herbalism for centuries for stress reduction and muscle tension. Supplement to be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

PS (Phosphatidylserine) Caps, 100 mg 100 capsules Phosphatidylserine is required for normal cellular structure and function. Brain tissues are especially rich in phosphatidylserine (PS), but aging causes a decline in the PS content of cells throughout the body. Research has shown that in addition to improving neural function, PS enhances energy metabolism in all cells, memory, concentration, learning and word choice. In the brain, PS helps maintain cell membrane integrity and youthful synaptic plasticity.81-90 A recent human study suggested chronic supplementation of phosphatidylserine significantly decreases cortical activity in the brain before and after induced stress, resulting in a more relaxed state.158 Consumption of phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly.83,86,91 However, the FDA concludes that there is still little scientific evidence supporting this claim.

Ginseng Adreno-Build 4050™ 60 tablets Rainbow Light's scientifically advanced Ginseng Adreno-Build 4050™ formula is designed to effectively promote the body's natural energy production. It delivers: Stimulant-Free Energy Support - with eleuthero, American ginseng and rhodiola, all researched for their effects on increasing stamina, mental alertness and work performance. Botanical catalysts support the action of the formula by enhancing endurance and nourishing the adrenal glands, featuring ashwagandha, Chinese licorice and rehmannia, while digestive herbs promote absorption. Targeted, Therapeutic Potency - with 4,050 mg of herbal powder strength equivalent per tablet, featuring standardized, whole plant extracts of eleuthero and American ginseng that are tested to guarantee a consistent amount of naturally occurring active constituents. Natural, Solvent-Free Extracts - unlike most standardized herbs extract with harsh chemical solvents that can leave residues, Rainbow Light's herbs are naturally extracted using alcohol or water, ensuring superior purity.

Vitamin C with Dihydroquercetin, 1000 mg 250 tablets Vitamin C, ascorbic acid, is a water-soluble substance found in citrus fruits and green vegetables. It is an important antioxidant that protects the body from free radicals and fights oxidative stress,41-44. A major immune-supporting activity of vitamin C is boosting glutathione levels in human lymphocytes,45 cells that make up about 25% of all white cells in the blood. Scientists have determined that the body needs high levels of vitamin C during periods of stress.46,47 Because humans do not manufacture vitamin C internally, it must be obtained through dietary sources or supplements. Vitamin C is a water-soluble nutrient that is quickly oxidized and excreted by the body,48. Until now, those seeking to capture vitamin C’s optimal health benefits have had no choice but to consume it several times throughout the day. A flavonoid antioxidant known as dihydroquercetin functions as a vitamin C “supercharger.” Studies demonstrate that dihydroquercetin acts to inhibit the oxidation of vitamin C, thereby helping maintain its concentration and recycle vitamin C throughout the body.49,50

DHEA (dehydroepiandrosterone) It has been shown that the serum hormone DHEA often declines by 75–80% from peak levels by age 70 or later, leading to hormonal imbalances that can affect one’s quality of life.1-3 Peak blood levels of DHEA occur at approximately age 25, decreasing progressively thereafter.3 The marked decline in serum DHEA with age is believed to play a role in health problems associated with aging. In a recent randomized, double-blind, placebo-controlled study, ten months of DHEA replacement therapy has the beneficial effect of enhancing the increases in muscle mass and strength with the addition of resistance exercise in elderly individuals.4 The studies of DHEA therapy in women with adrenal insufficiency also suggest beneficial effects on well-being, mood, and sexuality.5 DHEA could be of benefit to the normal aging brain.6-8 Ideally, DHEA replacement therapy should begin with blood testing to establish a base range. Since almost everyone over age 35–40 has lower than optimal levels of DHEA, most people begin supplementation and test their blood DHEA levels later to make sure they are taking the proper dose.

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